Related Experiment Video
Updated: Aug 17, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
[The effect of pyrazole on the conformational state of cell membrane phospholipids]
Abstract:
A change of conformation of phospholipids in the presence of pyrazole was studied by the method of 1H-NMR spectroscopy with the use of hydrophilic paramagnetic probes Pr3+. It was shown that the ratio of transformation of the polar groups of the bilayer surface of sonicated phosphatidyl-choline increased in the presence of pyrazole as compared to the experimental values of the induced pseudocontact shifts of the phosphorylcholine groups. It was established that the earlier discovered complexes of pyrazole-phospholipids in the inert solution exhibited in the water phase.
More Related Videos
Related Concept Videos
Membrane Fluidity
Membrane Fluidity
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Asymmetric Lipid Bilayer
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...

