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Regional distributions of beta-thalassemia mutations in Turkey
E O Atalay1, B Cirakoğlu, G Dinçolç
1Department of Biology, Marmara Research Center, Gebze, Kocaeli, Turkey.
International Journal of Hematology
|June 1, 1993
Abstract:
The distributions of twelve beta-thalassemic mutations in samples (n = 139 chromosomal samples) from four regions of Turkey were determined. The frequencies of these mutations did not reveal a notable region specific heterogeneity. In particular, the four mutations, IVS.1/nt.110(G/A), IVS.1/nt.6(T/C), IVS.1/nt.1(G/A) and nonsense codon.39(C/T), with country-scale frequencies of 35.9%, 21.6%, 13.0% and 7.2%, respectively, were found to be distributed with rather similar frequencies also on a regional scale.