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Nonsteroidal anti-inflammatory drugs for the prevention of colon cancer
1Division of Epidemiology and Preventive Oncology, Alberta Cancer Board, Edmonton.
Objective:
To summarize the results of animal and human studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on neoplastic growth in the colon and to outline the possible mechanisms involved.
Data Sources:
Research articles published in English before June 1992 were identified from MEDLINE.
Study Selection:
Nine articles on the polyp-cancer sequence were reviewed, 8 on the apparent pathophysiologic aspects of tumour inhibition by NSAIDs and 22 on animal and human research into the effect of NSAIDs on colon carcinogenesis.
Results:
The results of animal and human research into the anticarcinogenic effect of NSAIDs suggest that the drugs are effective in preventing tumour growth in the colon.
Conclusions:
Intervention studies in humans are necessary to elucidate the therapeutic possibilities of NSAIDs, particularly in populations at increased risk for the development of colon cancer.