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Pharmacocavernometry with prostaglandin E1

H O Nisén1, M L Ruutu

  • 1Fourth Department of Surgery, Helsinki University Central Hospital, Finland.

European Urology
|January 1, 1993
PubMed
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High-dose prostaglandin E1 pharmacostimulation for cavernometry shows cavernovenous leakage in most impotent patients, but the method

Area of Science:

  • Urology
  • Andrology
  • Pharmacology

Background:

  • Erectile dysfunction (impotence) diagnosis often requires objective assessment.
  • Pharmacocavernometry is a diagnostic tool used to evaluate erectile function.
  • High-dose prostaglandin E1 is utilized for pharmacostimulation in cavernometry.

Purpose of the Study:

  • To establish normal cavernometry parameter responses using high-dose prostaglandin E1.
  • To assess the repeatability of high-dose pharmacocavernometry.
  • To determine the incidence of cavernovenous leakage in impotent individuals.

Main Methods:

  • Pharmacocavernometry was performed on 82 impotent patients and 10 potent controls.
  • A high dose of 40 micrograms of prostaglandin E1 was used for pharmacostimulation.

Related Experiment Videos

  • Maintenance flow at 150 mm Hg (MF150) was measured in control subjects.

    • Main Results:

    • Normal MF150 in controls ranged from 3-22 ml/min (average 6 ml/min).
    • Repeatability of quantitative parameters in patients was found to be disappointing.
    • Cavernovenous leakage was estimated in 55-67% of impotent patients.

    Conclusions:

    • High-dose prostaglandin E1 pharmacocavernometry is valuable for selected impotent patients.
    • The consistency and repeatability of the cavernometry method require improvement.
    • The study highlights a high incidence of cavernovenous leakage in impotence.