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Corneal mucus plaques

F T Fraunfelder, P Wright, R C Tripathi

    American Journal of Ophthalmology
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Corneal mucus plaques can affect advanced dry eye disease (keratoconjunctivitis sicca). Topical 10% acetylcysteine effectively controls and prevents these plaques in most patients.

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    Area of Science:

    • Ophthalmology
    • Corneal Diseases
    • Dry Eye Disease

    Background:

    • Keratoconjunctivitis sicca (KCS) is a common condition causing dry eyes.
    • Advanced KCS can lead to corneal complications.
    • Corneal mucus plaques are a less common but significant finding in KCS.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of corneal mucus plaques in advanced KCS.
    • To evaluate the efficacy of 10% acetylcysteine in managing these plaques.

    Main Methods:

    • Observational study of 67 advanced KCS patients.
    • Clinical examination and ultrastructural analysis of corneal plaques.
    • Assessment of treatment outcomes with topical 10% acetylcysteine.

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    Main Results:

    • Corneal mucus plaques were found in 17 (25.4%) of advanced KCS cases.
    • Plaques varied in appearance, from translucent to opaque, and covered significant corneal areas.
    • Ultrastructural analysis revealed mucus, degenerated epithelial cells, and protein/lipid material.
    • Topical 10% acetylcysteine demonstrated control and prevention of plaques in most cases.

    Conclusions:

    • Corneal mucus plaques are a notable feature in a subset of advanced KCS patients.
    • These plaques are composed of a mixture of biological materials.
    • Topical 10% acetylcysteine is a viable therapeutic option for managing corneal mucus plaques in KCS.