Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaphylactic reaction to ranitidine

M Lázaro1, J A Compaired, B De La Hoz

  • 1Servicio de Alergia, Hospital Ramón y Cajal, Madrid, Spain.

Allergy
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Dual Super-Response in Patients With Asthma and CRSwNP Treated With Mepolizumab.

Journal of investigational allergology & clinical immunology·2025
Same author

Two Immediate Hypersensitivity Reactions to Isatuximab Confirmed by the Complement Activation Test and Treated With Successful Rapid Desensitization.

Journal of investigational allergology & clinical immunology·2025
Same author

Early Failure, Late Failure, and Sustained Response to Biologics in Severe Asthma: A Long-term, Real-world, Multicentre study.

Archivos de bronconeumologia·2025
Same author

Changes in macrozoobenthic assemblages of a coastal lagoon in the context of long-term human pressures and a eutrophication process.

Marine environmental research·2025
Same author

Reply to Correspondence: The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2025
Same author

The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2024
Same journal

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.

Allergy·2026
Same journal

Decoding the "Metallic" Immune Imprint: Single-Cell Exposomics Reveals the Immune Imprint of Fire Smoke.

Allergy·2026
Same journal

Immunonutrition in Early Life: The Role of Complementary Feeding, Dietary Patterns, and Nutritional Exposures on the Health of Young Children-An EAACI Scoping Review.

Allergy·2026
Same journal

Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.

Allergy·2026
Same journal

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
Same journal

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma.

Allergy·2026
See all related articles

Anaphylactic reactions to ranitidine are rare. This case study details a patient experiencing a severe allergic reaction, despite negative specific IgE tests, highlighting a potential hypersensitivity to this H2-receptor antagonist.

Area of Science:

  • Pharmacology
  • Immunology
  • Clinical Medicine

Background:

  • Ranitidine, a widely used H2-receptor antagonist, is generally well-tolerated.
  • Anaphylactic reactions to ranitidine are seldom reported in clinical practice.

Observation:

  • A patient presented with a confirmed anaphylactic reaction following ranitidine (Zantac) administration.
  • Diagnostic tests, including skin prick tests and oral challenges, indicated a type I hypersensitivity reaction.

Findings:

  • Specific immunoglobulin E (IgE) levels determined by radioallergosorbent test (RAST) were negative.
  • Histamine release tests with ranitidine also yielded negative results.
  • The patient showed no adverse reactions to other H2-receptor antagonists or to nitrofurantoin, another furan derivative.

Related Experiment Videos

Implications:

  • This case suggests ranitidine can induce anaphylaxis, potentially via mechanisms not solely dependent on specific IgE.
  • Further investigation into non-IgE mediated hypersensitivity or alternative diagnostic methods for ranitidine allergy may be warranted.
  • Clinicians should remain vigilant for rare allergic reactions to ranitidine, even with negative standard allergy testing.