Ecology and significance of Pasteurellaceae in man--an update

Within the last decade new knowledge has emerged concerning the significance of Pasteurellaceae in man; the classification has undergone some changes, and new taxa were described. Haemophilus influenzae serotype b was shown to have a clonal distribution that is related to demographic patterns of the human host. Brazilian purpuric fever is caused by a special clone of Haemophilus aegyptius. H. influenzae biotype IV seems to be a genital pathogen, and may deserve species rank. New Pasteurella species have been described, that occur in well known pathological foci in man, e.g. bite wounds. Toxigenic P. multocida may occur in man also; the significance of toxigenicity in man is not known. The real actinobacilli of man, A. ureae and A. hominis are still very rarely reported. In order to avoid wrong epidemiological conclusions, correct diagnosis is emphasized.