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Immune changes in test animals during spaceflight

A T Lesnyak1, G Sonnenfeld, M P Rykova

  • 1Institute of Biomedical Problems, Moscow, Russia.

Journal of Leukocyte Biology
|September 1, 1993
PubMed
Summary
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Spaceflight alters immune system parameters in astronauts and animal models. This review examines spaceflight-induced immune changes, including lymphocytic blastogenesis and cytokine function, to develop countermeasures.

Area of Science:

  • Immunology
  • Space Medicine
  • Space Biology

Background:

  • Immune system changes are observed in astronauts post-spaceflight.
  • Animal models are crucial for studying spaceflight-induced immune alterations.
  • Understanding these changes is key to developing countermeasures.

Purpose of the Study:

  • To review spaceflight-induced changes in immune parameters.
  • To investigate the mechanisms behind these immune alterations.
  • To discuss the significance of these immune changes.

Main Methods:

  • Review of existing literature on spaceflight and immunology.
  • Analysis of immune parameter changes in animal surrogates.
  • Focus on lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony-stimulating factors.
Keywords:
NASA Discipline Number 00-00NASA Discipline Number 18-10NASA Discipline Regulatory PhysiologyNASA Program FlightNASA Program Space Physiology and CountermeasuresNon-NASA Center

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Main Results:

  • Spaceflight leads to significant alterations in immune cell function.
  • Changes include altered lymphocytic blastogenesis and cytokine activity.
  • Natural killer cell activity and colony-stimulating factors are also affected.

Conclusions:

  • Spaceflight profoundly impacts the immune system.
  • Further research is needed to understand the mechanisms and develop effective countermeasures.
  • Animal models provide valuable insights into spaceflight immunology.