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Updated: Apr 19, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
Published on: January 13, 2019
[Immune system in Russian cosmonauts after orbital space flights]
Abstract:
The article is an overview of the results of studies of the immune systems of cosmonauts. The use of a system approach to the evaluation of the various components of the immune system made it possible to identify a number of characteristics of adaptive change, including the quantitative and functional changes of the innate and adaptive immunity. Among them the most important are: changes in in the system of Toll like receptors (TLRs) manifested as a decrease in the content of circulating monocytes and granulocytes expressing TLR2, TLR4, and TLR6, and LPS-induced cytokine production; inhibition of the functional potential of natural killer (NK)- and T-cells. The article discusses possible factors and mechanisms of the identified changes.
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