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Atypical ocular atopy

Y A Akova1, N S Jabbur, R Neumann

  • 1Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston 02114.

Ophthalmology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Atopic keratoconjunctivitis (AKC) can present without typical atopy signs. Conjunctival biopsy aids diagnosis, and treatment involves allergen control and medication, improving vision in affected patients.

Area of Science:

  • Ophthalmology
  • Allergy and Immunology
  • Dermatology

Background:

  • Atopic keratoconjunctivitis (AKC) is typically linked to atopic dermatitis.
  • Severe keratoconjunctivitis can manifest as the sole sign of atopy.
  • Presents three cases of chronic conjunctivitis with bilateral pannus formation without prior atopy history.

Observation:

  • Patients underwent evaluation for collagen vascular disease and atopy.
  • Conjunctival biopsies were analyzed using light microscopy and immunohistochemistry.
  • Systemic evaluation for collagen vascular disease was negative.

Findings:

  • Conjunctival biopsy revealed characteristic histopathologic findings suggestive of atopy in all patients.
  • Elevated serum IgE levels were noted in one patient.

Related Experiment Videos

  • All patients responded positively to allergen environmental control, topical cromolyn sodium, and systemic antihistamines, resolving conjunctivitis.

    • Implications:

    • Atopy should be considered in external ocular inflammation cases, even without systemic atopy indicators.
    • Conjunctival biopsy is a valuable diagnostic method for atypical atopic keratoconjunctivitis.
    • Early diagnosis and management can prevent progressive, sight-threatening consequences.