Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercholesterolemia and angiogenesis

P D Henry1

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.

The American Journal of Cardiology
|September 9, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet.

Archives of biochemistry and biophysics·2014
Same author

Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.

Circulation·2001
Same author

Oxidized low-density lipoproteins inhibit endothelial cell proliferation by suppressing basic fibroblast growth factor expression.

Circulation·2000
Same author

Shocks as predictors of survival in patients with implantable cardioverter-defibrillators.

Journal of the American College of Cardiology·1999
Same author

Prevention of implantable-defibrillator shocks by treatment with sotalol. d,l-Sotalol Implantable Cardioverter-Defibrillator Study Group.

The New England journal of medicine·1999
Same author

Comparison of results in two implantable defibrillators. Jewel 7219D Investigators.

The American journal of cardiology·1998
Same journal

Real-World Effectiveness and Tolerability of Sacubitril/Valsartan in Octogenarian Patients With Heart Failure: Results From the PARACHUTER Study.

The American journal of cardiology·2026
Same journal

ECG-Guided Conduction Pathways as a Lever to Shorten Post-TAVI Hospitalization.

The American journal of cardiology·2026
Same journal

Cystatin-C versus creatinine and kidney function in heart failure with preserved ejection fraction: a SOGALDI-PEF analysis.

The American journal of cardiology·2026
Same journal

Balloon-expandable versus Self-expanding Valves in Patients with Small Aortic Annuli Undergoing Transcatheter Aortic Valve Replacement.

The American journal of cardiology·2026
Same journal

Drug-Coated Balloons versus Drug-Eluting Stents following Coronary Atherectomy in Severely Calcified Lesions: A Systematic Review and Meta-Analysis.

The American journal of cardiology·2026
Same journal

Prehospital Statin Therapy and Outcomes in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

The American journal of cardiology·2026
See all related articles

High cholesterol impairs endothelial cell replication, hindering vascular growth and potentially contributing to atherosclerosis. This study reveals a key mechanism in hypercholesterolemia

Area of Science:

  • Cardiovascular Biology
  • Atherosclerosis Research

Background:

  • Hypercholesterolemia is linked to endothelial cell dysfunction.
  • Toxic lipoprotein degradation products may accumulate in artery walls.
  • Oxidized low-density lipoprotein can impair cell signaling and responsiveness.

Purpose of the Study:

  • To investigate the impact of hypercholesterolemia on endothelial cell replication.
  • To understand the role of impaired endothelial replication in vascular growth and atherosclerosis.

Main Methods:

  • Experiments were conducted using intact rabbits.
  • The study focused on endothelial cell replication in the context of hypercholesterolemia.

Main Results:

  • Endothelial cell replication, crucial for vascular growth, was significantly impaired in hypercholesterolemic rabbits.

Related Experiment Videos

  • This impairment affects the growth of arterial channels and angiogenesis.

    • Conclusions:

    • Hypercholesterolemia-induced endothelial dysfunction involves impaired replication.
    • This defect is a significant factor in the pathophysiology of occlusive atherosclerotic disease.