Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sexual differences in sensitivity to methamphetamine toxicity

G C Wagner1, T L Tekirian, C T Cheo

  • 1Department of Psychology, Rutgers University, New Brunswick, NJ.

Journal of Neural Transmission. General Section
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased maternal behavior and anxiety in ephrin-A5<sup>-/-</sup> mice.

Genes, brain, and behavior·2016
Same author

Electron spin relaxation measurements on the blue-copper protein plastocyanin: Deviations from a power law temperature dependence.

Biophysical journal·2009
Same author

Egr1 involvement in evening gene regulation by melatonin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2008
Same author

Inhibitory effects of ginseng total saponin on methamphetamine-induced striatal dopamine increase in mice.

Archives of pharmacal research·2008
Same author

Acute and chronic effects of ginseng total saponin and amphetamine on fixed-interval performance of rats.

Planta medica·2007
Same author

Trimethyltin-induced alterations in behavior are linked to changes in PSA-NCAM expression.

Neurotoxicology·2006
Same journal

Effects of neonatal clomipramine on cholinergic receptor sensitivity and passive avoidance behavior in adult rats.

Journal of neural transmission. General section·1995
Same journal

Expression of neuronal acetylcholine nicotinic receptor alpha 4 and beta 2 subunits during postnatal development of the rat brain.

Journal of neural transmission. General section·1995
Same journal

Homocysteinemia is a common feature of schizophrenia.

Journal of neural transmission. General section·1995
Same journal

MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice.

Journal of neural transmission. General section·1995
Same journal

Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.

Journal of neural transmission. General section·1995
Same journal

Striatal dopaminergic D1 and D2 receptors after intracerebroventricular application of alloxan and streptozocin in rat.

Journal of neural transmission. General section·1995
See all related articles

Methamphetamine caused greater dopamine depletions in male mice than female mice. Estrogen may protect against methamphetamine-induced dopamine loss, potentially explaining sex differences in Parkinson's disease risk.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Endocrinology

Background:

  • Methamphetamine is a neurotoxin that depletes dopamine.
  • Sex differences exist in the prevalence of neurodegenerative diseases like Parkinson's disease.

Purpose of the Study:

  • To investigate sex differences in methamphetamine-induced dopamine depletions in mice.
  • To explore the potential protective role of estrogen against methamphetamine neurotoxicity.

Main Methods:

  • Male and female mice received methamphetamine (10.0 mg/kg/injection, four injections).
  • Striatal dopamine levels were measured two weeks post-treatment.

Main Results:

  • Methamphetamine caused significant striatal dopamine depletions in both sexes.

Related Experiment Videos

  • Males exhibited greater dopamine depletions (74%) compared to females (56%).

    • Conclusions:

    • Estrogen may offer a protective effect against methamphetamine-induced dopamine depletions.
    • These findings may contribute to understanding sex-based differences in Parkinson's disease susceptibility.