[3 years experience with the Capture-R-Solid Phase antibody identification test]

Solid-phase capture methodology is very helpful to find and identify red cell antibodies. Cold agglutinins like anti-I, anti-H, anti-IH, anti-P1, anti-Lea, anti-Leb, anti-M, or anti-N cannot be detected if they are isolated IgM class antibodies. It is very doubtful that these antibodies are of any clinical importance. We missed one IgM Anti-Lea, but we found additional 40 IgG class antibodies with known clinical importance which neither could be detected nor identified by conventional test procedures.