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GH releasing peptides--structure and kinetics

C Y Bowers1

  • 1Tulane University Medical Center, New Orleans, LA 70112.

The Journal of Pediatric Endocrinology
|January 1, 1993
PubMed
Summary

New synthetic peptides, growth hormone-releasing peptides (GHRPs), effectively release growth hormone (GH) in humans via oral or intravenous administration. These GHRPs show significant potential for therapeutic applications.

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Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • A novel class of synthetic peptides, 6-7 amino acids in length, has been developed for specific growth hormone (GH) release.
  • Three such peptides, GHRP-6, GHRP-1, and GHRP-2, have been administered to humans, demonstrating dose-dependent GH release.

Purpose of the Study:

  • To evaluate the efficacy of GHRPs in releasing GH across different administration routes (intravenous, subcutaneous, oral) in healthy adults.
  • To investigate the potential of oral GHRP-6 in inducing GH release in children with GH deficiency.
  • To assess the synergistic effect of combined GHRP-1 and GHRH administration on GH release.

Main Methods:

  • Administration of GHRP-6, GHRP-1, and GHRP-2 via intravenous (IV), subcutaneous (SC), and oral routes in healthy men and women.
  • Assessment of GH responses and serum irGHRP levels following administration.
  • Oral administration of GHRP-6 to children with varying degrees of GH deficiency.
  • Combined IV administration of GHRP-1 and GHRH 1-44NH2.

Main Results:

  • All three GHRPs (GHRP-6, GHRP-1, GHRP-2) demonstrated effective GH release in humans, surpassing GHRH 1-44NH2 in efficacy.
  • Oral administration of GHRP-6, GHRP-1, and GHRP-2 successfully induced GH release, with GHRP-1 and GHRP-2 achieving near-maximal levels.
  • Oral GHRP-6 stimulated GH release in children with GH deficiency.
  • A synergistic GH release was observed with the combined IV administration of GHRP-1 and GHRH 1-44NH2.

Conclusions:

  • GHRPs represent a promising class of compounds for stimulating GH release, effective through multiple administration routes, including oral.
  • These peptides hold significant theoretical and pharmaceutical potential for managing conditions related to GH deficiency.

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