Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Participation of complement in nasal polyposis

J Zídková1, V Stĕdrý, V Zídek

  • 1Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.

Folia Microbiologica
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanoparticle-Modified Apoferritin Nanotransfer for Targeted Cytostatic Transport.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2019
Same author

The effect of zinc and/or vitamin E supplementation on biochemical parameters of selenium-overdosed rats.

Polish journal of veterinary sciences·2019
Same author

Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.

Physiological research·2018
Same author

Genetically determined folate deficiency is associated with abnormal hepatic folate profiles in the spontaneously hypertensive rat.

Physiological research·2018
Same author

Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity.

Physiological research·2017
Same author

Visfatin is actively secreted in vitro from U-937 macrophages, but only passively released from 3T3-L1 adipocytes and HepG2 hepatocytes.

Physiological research·2017
Same journal

Lactobacillus strains in the prevention and disruption of antimicrobial-resistance in pathogenic microbial biofilms: a review of mechanisms and clinical perspective.

Folia microbiologica·2026
Same journal

Synergistic effects of a lytic Salmonella bacteriophage cocktail and selected antimicrobial agents on Salmonella enterica serovar Enteritidis.

Folia microbiologica·2026
Same journal

Machine learning-guided discovery of spirocyclic inhibitors targeting Mycobacterium tuberculosis FtsZ.

Folia microbiologica·2026
Same journal

Multifunctional bioactivity of Echinops niveus: Antimicrobial, antioxidant, and cytotoxic evaluation.

Folia microbiologica·2026
Same journal

Molecular epidemiology and clinical course of PVL-positive MRSA CC398 infections.

Folia microbiologica·2026
Same journal

Proline treatment improves salinity tolerance in the green microalga Dunaliella sp. by altering carbon partitioning and inducing metabolites accumulation.

Folia microbiologica·2026
See all related articles

Nasal polyposis patients show no changes in immunoglobulin or complement C3/C4 levels. However, both acute and recurrent nasal polyposis significantly decrease alternative complement pathway activation, with acute cases also showing reduced classical pathway activity.

Area of Science:

  • Immunology
  • Otorhinolaryngology
  • Complement System Biology

Background:

  • Nasal polyposis is a chronic inflammatory condition of the upper airway.
  • Immunoglobulin and complement system alterations are implicated in inflammatory diseases.
  • Understanding complement activation in nasal polyposis is crucial for disease management.

Purpose of the Study:

  • To investigate immunoglobulin and complement component levels in patients with acute and recurrent nasal polyposis.
  • To evaluate the status of complement activation pathways (classical and alternative) in these patient groups.
  • To determine the clinical utility of assessing complement pathways for disease follow-up.

Main Methods:

  • Serum samples were collected from patients with acute and recurrent nasal polyposis.

Related Experiment Videos

  • Levels of immunoglobulins (IgG, IgM, IgA) and complement components (C3, C4) were measured.
  • Functional assays were performed to assess the activity of the classical and alternative complement pathways.

    • Main Results:

    • No significant differences were observed in IgG, IgM, IgA, C3, or C4 levels between patient groups and controls.
    • A substantial reduction (up to 80%) in alternative complement pathway activation was found in both acute and recurrent nasal polyposis.
    • Patients with acute nasal polyposis exhibited a notable decrease (up to 20%) in classical complement pathway activity.

    Conclusions:

    • Immunoglobulin and C3/C4 levels are not significantly altered in nasal polyposis.
    • Complement activation pathways, particularly the alternative pathway, are significantly impaired in nasal polyposis.
    • Monitoring complement activation pathways may offer valuable insights for tracking the progression of nasal polyposis.