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[The histamine-free diet]

F Wantke1, M Götz, R Jarisch

  • 1Dermatologisches und pädiatrisches Allergieambulatorium Wien.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|August 1, 1993
PubMed
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Food intolerance is often caused by histamine, not allergies. A histamine-free diet significantly improved symptoms in over half of patients, suggesting a deficiency in histamine breakdown contributes to food intolerance.

Area of Science:

  • Allergy and Immunology
  • Gastroenterology
  • Nutrition Science

Context:

  • Food intolerance is a common condition often confused with allergies.
  • Histamine intolerance is increasingly recognized as a significant factor in adverse food reactions.
  • Diaminoxidase (DAO) deficiency is a suspected cause of impaired histamine metabolism.

Purpose:

  • To evaluate the therapeutic efficacy of a histamine-free diet in patients with food intolerance and allergic diseases.
  • To investigate the role of histamine in triggering or exacerbating symptoms in susceptible individuals.

Summary:

  • A 4-week histamine-free diet was administered to 100 patients with food intolerance and allergic conditions.
  • Significant symptom improvement was observed in 57% of patients, with 15% achieving total remission.

Related Experiment Videos

  • High efficacy was noted for food/wine intolerance (80%), asthma (80%), headache (64%), and urticaria (58%).
  • Recurrence of atopic eczema was observed in 50% of affected patients after histamine-rich food ingestion.

    • Impact:

    • Histamine plays a crucial role in food and wine intolerance, as well as exacerbating symptoms in atopic individuals and those with headaches.
    • The findings suggest a deficiency in diaminoxidase (DAO) in patients experiencing intolerance to food or wine.
    • This research supports the need for labeling histamine content in alcoholic beverages to aid patient management.