Simultaneous determination of 6-monoacetylmorphine, morphine and codeine in urine using high-performance liquid
J Gerostamoulos1, K Crump, I M McIntyre
1Victorian Institute of Forensic Pathology, Monash University, South Melbourne, Australia.
Journal of Chromatography
|July 23, 1993
Abstract:
A method is described for the simultaneous determination of 6-monoacetylmorphine (6-MAM), morphine and codeine in post-mortem urine specimens using reversed-phase high-performance liquid chromatography with dual ultraviolet spectrophotometric and electrochemical detection. The limits of detection for a 1-ml urine sample were 0.04 mg/l for 6-MAM and 0.05 mg/l for both morphine and codeine. The presence of 6-MAM in urine indicates prior use of heroin and enables differentiation between morphine- and heroin-related deaths.


