Related Experiment Videos
Pattern of deep venous thrombosis in Jeddah area, western Saudi Arabia
H al Zahrani1, M Gari, S Sejeni
1Department of *Surgery and Haematology, King Abdulaziz University, Jeddah, Saudi Arabia.
Insights
Deep Vein Thrombosis (DVT) patterns in Jeddah reveal common risk factors like age, obesity, and postpartum status. A significant portion of cases were idiopathic or linked to rare clotting disorders, highlighting diagnostic challenges.
Area of Science:
- Vascular Medicine
- Hematology
- Epidemiology
Background:
- Deep Vein Thrombosis (DVT) is a significant vascular condition with limited epidemiological data in Saudi Arabia.
- Understanding the specific patterns and risk factors of DVT in the Jeddah region is crucial for targeted prevention and treatment strategies.
Purpose of the Study:
- To investigate the epidemiological patterns of Deep Vein Thrombosis (DVT) in Jeddah, Western Saudi Arabia.
- To identify common risk factors, including rare inherited and acquired thrombophilias, associated with DVT in this population.
Main Methods:
- A retrospective study analyzing 62 confirmed cases of venous thrombosis over a 4-year period.
- Data collection included patient demographics, identified risk factors, laboratory investigations for thrombophilia, and anatomical location of thrombosis.
Main Results:
- The study included 62 patients (32 female, 30 male) with a mean age of 36.0 years.
- Common risk factors identified in 40 patients were advanced age (>50 years), obesity, vasculitis, malignancy, and postpartum status.
- Of the 22 patients without apparent risk factors, 9 had diagnosed rare disorders (Antithrombin III, Protein C, Protein S deficiencies) and 13 (21%) were classified as idiopathic DVT.
- Extremities were the most common site of thrombosis (54 patients), predominantly the lower limbs (37 patients) compared to upper limbs (10 patients).
Conclusions:
- Deep Vein Thrombosis (DVT) in Jeddah presents with a mix of identifiable risk factors and a notable proportion of idiopathic cases, some linked to rare thrombophilias.
- The findings underscore the need for comprehensive diagnostic workups in suspected DVT patients, even in the absence of typical risk factors.
- Lower limb deep vein thrombosis is the predominant manifestation in this Saudi Arabian cohort.
Abstract:
Little is known about the pattern of Deep Vein Thrombosis in Saudi Arabia. Over 4 year period, 62 cases with strong evidence of venous thrombosis were studied in King Abdulaziz University and King Fahad Hospitals to learn the pattern of deep vein thrombosis in Jeddah, Western Saudi Arabia. There were 32 females and 30 males. The mean age of the group was 36.0 years (range 6-90 years). One or more risk factors was/were detected in 40 patients. Among these 14 factors, age more than 50 years, obesity, vasculitis, malignancy and postpartum were the common factors encountered. In other 22 patients, no risk factor was found. However, extensive laboratory search diagnosed 9 rare disorders out of these 22 cases. Antithrombin III, protein C, protein S deficiencies in 5, 2, 1 patients, consecutively. The last patient had significantly shortened PTT. The other 13 (21.0%) patients were considered real idiopathic DVT. Extremities were involved in 54 patients compared to only 8 cases with inferior vena cava or visceral thrombosis. The upper limb was affected in only 10 patients unlike the lower limb which was more commonly affected n = 37.