Perilesional vitiligo in melanoma

The malignant transformation of a plantar nevus is presented. Perilesional vitiligo developed concurrently with the onset of malignancy. The primary lesion was controlled surgically, but the patient succumbed to metastiatic melanoma within a year. The relation of perilesional vitiligo in malignant melanoma to the so-called halo nevus, and the immunologic significance of these discolorations is reviewed.