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[Experimental autoimmune uveitis and retinitis induced by S-antigen immunization]
M Misiuk-Hojło1, J Ruiz-Moreno, B Thillaye
1Laboratorium Immunopatologii Oka, INSERM U 86, Paryzu.
Klinika Oczna
|March 1, 1993
Abstract:
Experimental autoimmune uveoretinitis (EAU) was induced in Lewis rats by a single injection in foot pads of S-antigen in complete Freund's adjuvant. Clinically, during the 2 nd week after immunization, EAU starts by acute anterior, lately--posterior uveitis. Peptide S2, located in the N-terminal region of S-antigen, has a regulatory effect on EAU, while peptide M is a pathogenic site inducing EAU. Antibodies directed at peptide S2 were observed in rats not developing EAU while high levels of antibodies directed at S-antigen and peptide M were present in all rats.