Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD44 and its interaction with extracellular matrix

J Lesley1, R Hyman, P W Kincade

  • 1Department of Cancer Biology, Salk Institute, San Diego, California 92186.

Advances in Immunology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A survey of diabetes services in hospitals in Papua New Guinea.

Papua and New Guinea medical journal·2002
Same author

Type 1 diabetes mellitus in children in Papua New Guinea.

Papua and New Guinea medical journal·2002
Same author

Age and stage dependency of estrogen receptor expression by lymphocyte precursors.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Adding value to clinical data by linkage to a public death registry.

Studies in health technology and informatics·2001
Same author

Type I interferons and limitin: a comparison of structures, receptors, and functions.

Cytokine & growth factor reviews·2001
Same author

Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same journal

The roles and diversity of alarmins in the mucosae.

Advances in immunology·2026
Same journal

Principles of resident tissue macrophages revealed by the eye.

Advances in immunology·2026
Same journal

Beyond suppression: Treg specialization in infection and tissue repair.

Advances in immunology·2026
Same journal

Ontogeny and function of microglia and nerve-associated macrophages.

Advances in immunology·2025
Same journal

Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues.

Advances in immunology·2025
Same journal

Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination.

Advances in immunology·2025
See all related articles

CD44, a cell adhesion receptor, interacts with hyaluronan to trigger diverse cellular responses. Its function and isoforms are crucial in hematopoiesis, immune responses, and malignancy, with ligand binding tightly regulated.

Area of Science:

  • Cell Biology
  • Immunology
  • Molecular Biology

Background:

  • CD44 functions as a cell adhesion receptor, with hyaluronan as a primary ligand.
  • Both CD44 and hyaluronan are widely distributed in extracellular matrices and fluids.
  • CD44 ligation elicits a wide array of cellular responses, including adhesion, migration, and differentiation.

Purpose of the Study:

  • To explore the diverse cellular responses mediated by CD44 ligation.
  • To investigate the role of CD44 in hematopoiesis and immune responses.
  • To understand the regulation of CD44 ligand-binding function and the significance of its isoforms.

Main Methods:

  • Analysis of CD44 expression and function in various cell types.
  • Investigation of CD44's role in hematopoietic differentiation and immune cell activation.

Related Experiment Videos

  • Examination of CD44 alternative splicing and post-translational modifications.

    • Main Results:

    • CD44 ligation induces varied downstream events dependent on cell type and environment.
    • CD44 is involved in early hematopoiesis and upregulated in lymphocytes upon antigenic stimulation.
    • CD44 ligand binding is tightly regulated, with activation dependent on differentiation and signaling.
    • Multiple CD44 isoforms exist, with some linked to malignancies and metastasis.

    Conclusions:

    • CD44's diverse functions are context-dependent, influenced by cell type and microenvironment.
    • Regulation of CD44 ligand binding provides specificity to cellular interactions.
    • CD44 isoforms may play significant roles in disease, including cancer progression.