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Diatrizoate in computed cranial tomography: a quantitative study

I E Leppik, C J Thompson, R Ethier

    Investigative Radiology
    |January 1, 1977
    PubMed
    Summary
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    This study determined optimal diatrizoate dosing for computed cranial tomography (CCT) contrast enhancement. Lowering beam energy improved lesion visualization, suggesting a link between contrast index and lesion vascularity.

    Area of Science:

    • Radiology
    • Medical Imaging
    • Pharmacokinetics

    Background:

    • Computed cranial tomography (CCT) requires effective contrast agents for accurate lesion detection.
    • Optimizing plasma concentrations of contrast media like diatrizoate is crucial for diagnostic imaging.
    • Understanding the relationship between contrast dose, imaging parameters, and lesion characteristics is essential.

    Purpose of the Study:

    • To establish optimal plasma concentrations of diatrizoate for CCT.
    • To evaluate the impact of reduced beam energy on diatrizoate visualization.
    • To explore the correlation between a contrast index and lesion vascularity/extravasation.

    Main Methods:

    • Plasma diatrizoate concentrations were measured using UV spectrophotometry in 14 patients undergoing CCT.

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  • A specific loading dose and continuous infusion regimen was administered to achieve target plasma levels.
  • Beam energy was systematically lowered, and the effect on EMI numbers and lesion delineation was assessed.
  • A contrast index was calculated for diagnosed lesions to quantify diatrizoate uptake.

    • Main Results:

    • A loading dose of 0.82 mg/kg followed by a 0.01 mg/kg/h infusion achieved and maintained plasma diatrizoate levels around 400 mg/100 ml.
    • Reducing beam energy significantly increased diatrizoate's EMI numbers, enhancing contrast-filled lesion visibility.
    • The calculated contrast index showed a relationship with lesion vascularity and extravasation.

    Conclusions:

    • The study defines an effective dosing strategy for diatrizoate in CCT.
    • Lowering beam energy is a valuable technique for improving contrast-enhanced lesion detection in CCT.
    • The contrast index may serve as a useful indicator of lesion vascularity and extravasation in CCT imaging.