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Comparative study of human cancellous bone remodeling to titanium and hydroxyapatite-coated implants
A A Hofmann1, K N Bachus, R D Bloebaum
1Bone and Joint Research Labs, VA Medical Center, Salt Lake City, UT 84148.
The Journal of Arthroplasty
|April 1, 1993
Summary
Hydroxyapatite (HA) coatings on knee implants enhanced bone ingrowth by 8% but showed slightly lower bone mineral content. Precision placement is crucial for optimal integration of HA coatings with cancellous bone.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Tissue Engineering
Background:
- Porous hydroxyapatite (HA) and titanium coatings are used on orthopedic implants.
- Understanding cancellous bone response to these coatings is vital for implant success.
Purpose of the Study:
- To compare the human cancellous bone response to porous hydroxyapatite (HA) and titanium-coated implants.
- To quantify bone ingrowth, mineral apposition rate, and bone mineral content.
Main Methods:
- Bilateral knee patients received weight-bearing porous HA and titanium-coated implants.
- Bone ingrowth, mineral apposition rate, and bone mineral content were quantified.
Main Results:
- Osteoconductive HA coating increased bone ingrowth by 8% (P = .018).
- HA coating did not affect mineral apposition rate.
- HA coating resulted in 8% lower bone mineral content at the implant interface (P = .042).
Conclusions:
- HA coatings enhance bone ingrowth in cancellous bone but may reduce mineral content.
- The influence of HA coatings is focal, requiring precise placement adjacent to bone.
- Further research is needed to optimize HA coating integration with human cancellous bone.