Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New developments with herpesviruses and the nervous system

F J Picard1, S D Poland, G P Rice

  • 1University of Western Ontario, University Hospital, London, Canada.

Current Opinion in Neurology and Neurosurgery
|April 1, 1993
PubMed
Summary

Human herpesviruses establish unique relationships with the central nervous system, causing illnesses through direct effects, immune responses, or cancer. This review covers latency, neuroinflammatory diseases, and new diagnostics and treatments for these viral infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a real-time PCR assay for the specific detection and identification of Streptococcus pseudopneumoniae using the recA gene.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2011
Same author

Clostridium lavalense sp. nov., a glycopeptide-resistant species isolated from human faeces.

International journal of systematic and evolutionary microbiology·2009
Same author

Ruminococcus gauvreauii sp. nov., a glycopeptide-resistant species isolated from a human faecal specimen.

International journal of systematic and evolutionary microbiology·2008
Same author

Treatment of secondary progressive multiple sclerosis: current recommendations and future prospects.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same author

vanD and vanG-like gene clusters in a Ruminococcus species isolated from human bowel flora.

Antimicrobial agents and chemotherapy·2007
Same author

High prevalence of glycopeptide resistance genes vanB, vanD, and vanG not associated with enterococci in human fecal flora.

Antimicrobial agents and chemotherapy·2005

Area of Science:

  • Neurovirology
  • Immunology
  • Infectious Diseases

Background:

  • Human herpesviruses exhibit a specialized tropism for the central nervous system (CNS).
  • Understanding the interplay between herpesviruses and the CNS is crucial for managing neurological disorders.

Purpose of the Study:

  • To review recent advancements in the mechanisms of herpesvirus latency in the CNS.
  • To discuss diverse neuropathologies arising from viral cytopathic effects, immune activation, and oncogenesis.
  • To highlight herpesvirus implications in acquired immunodeficiency syndrome (AIDS) and neonatal infections, alongside novel diagnostic and therapeutic strategies.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of data on viral latency, pathogenesis, and clinical manifestations.

Related Experiment Videos

  • Analysis of emerging diagnostic tools and treatment modalities.

    • Main Results:

    • Herpesviruses establish persistent infections in the CNS through various latency mechanisms.
    • Neurological diseases result from direct viral damage, immune-mediated inflammation, and virus-associated malignancies.
    • Herpesvirus infections pose significant risks in immunocompromised individuals (e.g., AIDS patients) and neonates.
    • Advancements in diagnostics and treatments offer improved management options.

    Conclusions:

    • Herpesvirus infections of the CNS are complex, involving intricate viral-CNS interactions.
    • Continued research into latency, pathogenesis, and host responses is essential.
    • Novel diagnostic and therapeutic approaches are improving patient outcomes for these challenging infections.