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Related Experiment Videos

Morphine antagonizes U50,488's effects in a squirrel monkey shock titration procedure

R M Craft1, L A Dykstra

  • 1Department of Psychology, University of North Carolina, Chapel Hill 27599-3270.

European Journal of Pharmacology
|April 6, 1993
PubMed
Summary
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Morphine, a mu opioid agonist, weakly antagonizes kappa opioid effects in squirrel monkeys. This antagonism is dose-dependent and influenced by morphine tolerance, suggesting complex opioid interactions.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Behavioral Science

Background:

  • Opioid agonists interact with specific receptors, influencing physiological and behavioral responses.
  • Understanding opioid interactions is crucial for pain management and addiction research.

Purpose of the Study:

  • To investigate the modulatory effects of a mu opioid agonist (morphine) on a kappa opioid agonist (U50,488) in a squirrel monkey model.
  • To assess the impact of morphine tolerance on these opioid interactions.

Main Methods:

  • Squirrel monkeys were subjected to a shock titration procedure.
  • Morphine was administered alone and in combination with U50,488.
  • Dose-effect curves for U50,488 were analyzed before and after chronic morphine administration.

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Main Results:

  • Acute morphine administration showed dose-dependent antagonism of later U50,488 effects, but not early peak effects.
  • Chronic morphine administration resulted in a greater rightward shift of the U50,488 dose-effect curve.
  • Morphine demonstrated weak kappa antagonist activity, particularly in non-tolerant monkeys.

Conclusions:

  • Morphine exhibits weak kappa antagonist properties in the shock titration procedure.
  • Morphine's mu agonist activity and tolerance development influence its kappa antagonist efficacy.
  • These findings highlight the complex interplay between mu and kappa opioid receptor systems.