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Published on: March 30, 2018
A translocation (8;14) in a cutaneous large B-cell lymphoma
A M Busschots1, M L Geerts, C Mecucci
1Centre for Human Genetics, University of Leuven, Belgium.
American Journal of Clinical Pathology
|May 1, 1993
Summary
This study details a rare case of cutaneous large-cell lymphoma in a 62-year-old man, identifying specific chromosomal abnormalities and Epstein-Barr virus association. Findings contribute to understanding B-cell non-Hodgkin
Area of Science:
- Oncology
- Genetics
- Immunology
Background:
- Cutaneous lymphomas represent a diverse group of non-Hodgkin lymphomas.
- Understanding the specific genetic and viral factors is crucial for accurate diagnosis and treatment.
Observation:
- A 62-year-old male presented with facial lesions and cervical lymphadenopathy, diagnosed as cutaneous large-cell lymphoma.
- Cytogenetic analysis revealed a complex karyotype: 47,XY,inv dup(1)(q11-->q32),+3,t(8;14)(q24;q32).
- Immunogenotyping confirmed immunoglobulin gene rearrangement, and serology was positive for Epstein-Barr virus (EBV) antigens.
Findings:
- The t(8;14)(q24;q32) translocation, common in Burkitt's lymphoma, was identified.
- Additional chromosomal aberrations included duplication of chromosome 1 long arm material and trisomy 3.
- While EBV antibodies were present, EBV DNA integration into tumor tissue was not detected via PCR.
Implications:
- The identified genetic profile provides insights into the biology of this specific cutaneous B-cell non-Hodgkin lymphoma.
- Correlation of cytogenetic findings with EBV status may aid in classifying and potentially managing similar cases.
- This case highlights the importance of comprehensive molecular analysis in non-Hodgkin lymphoma diagnosis.
