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Palisaded intranodal myofibroblastoma. Electron microscopic study
M Michal1, A Chlumská, A Skálová
1Sikl's Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic.
Zentralblatt Fur Pathologie
|March 1, 1993
Summary
This study details the ultrastructural characteristics of palisaded intranodal myofibroblastomas. Findings suggest tumor cells may originate from modified smooth muscle cells, offering insights into tumor development.
Area of Science:
- Oncology
- Pathology
- Cell Biology
Background:
- Palisaded intranodal myofibroblastoma is a rare tumor.
- Understanding its ultrastructural features is crucial for diagnosis and treatment.
Purpose of the Study:
- To describe the ultrastructural characteristics of three cases of palisaded intranodal myofibroblastoma.
- To investigate the origin of tumor cells and associated vascular proliferation.
Main Methods:
- Ultrastructural analysis using electron microscopy.
- Histopathological examination of tumor tissues.
Main Results:
- Tumor cells identified as myofibroblasts.
- Abortive vessels and extratumoral proliferation composed of similar myofibroblasts.
- Evidence suggests origin from modified smooth muscle cells.
- Stages of intracytoplasmic fuchsinophilic body formation observed.
Conclusions:
- Palisaded intranodal myofibroblastomas are composed of myofibroblasts.
- Tumorous myofibroblasts may originate from modified smooth muscle cells.
- Ultrastructural findings provide insights into the pathogenesis of this rare tumor.