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Gamma delta T-cell development

J P Allison1

  • 1Cancer Research Laboratory, University of California, Berkeley 94720.

Current Opinion in Immunology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Gamma delta T cells develop through programmed gene rearrangement, not cellular selection. This process shapes their diverse T-cell receptor repertoires and functions.

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Area of Science:

  • Immunology
  • Cellular Biology
  • Genetics

Background:

  • Gamma delta T cells are a diverse immune cell lineage.
  • These cells exhibit distinct antigen receptor repertoires, tissue localization, and functions.
  • Their development involves specific T-cell receptor gene rearrangements.

Purpose of the Study:

  • To investigate the developmental mechanisms shaping gamma delta T cell lineages.
  • To determine the role of gene rearrangement versus cellular selection in T-cell receptor repertoire formation.

Main Methods:

  • Analysis of V gamma-gene segment rearrangement patterns during T cell development.
  • Characterization of T-cell receptor repertoires in invariant gamma delta T cells.

Main Results:

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  • Evidence suggests programmed rearrangement of V gamma-gene segments dictates sublineage appearance.
  • The T-cell receptor repertoire of invariant gamma delta T cells arises from site-directed rearrangement.
  • Cellular selection plays a minimal role in shaping this repertoire.

Conclusions:

  • Gamma delta T cell lineage diversification is primarily driven by programmed V gamma-gene rearrangement.
  • The T-cell receptor repertoire is largely predetermined by genetic rearrangement processes.
  • This programmed development ensures specific immune functions and tissue homing.