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Hepatocellular tumors: characterization with Mn-DPDP-enhanced MR imaging
N M Rofsky1, J C Weinreb, M E Bernardino
1Department of Radiology, New York University Medical Center, Tisch Hospital, NY 10016.
Radiology
|July 1, 1993
Summary
Manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (Mn-DPDP) magnetic resonance (MR) imaging effectively distinguishes hepatocellular tumors. This hepatobiliary contrast agent shows high accuracy in identifying liver cancer origins.
Area of Science:
- Hepatobiliary Magnetic Resonance Imaging
- Oncology
- Radiology
Background:
- Focal hepatic diseases require accurate diagnostic tools.
- Distinguishing hepatocellular from non-hepatocellular tumors is clinically significant.
- Hepatobiliary contrast agents enhance MR imaging for liver lesion characterization.
Purpose of the Study:
- To evaluate the efficacy of manganese (II) N,N '-dipyridoxylethylenediamine-N,N '-diacetate 5,5 '-bis(phosphate) (Mn-DPDP) enhanced MR imaging.
- To determine if Mn-DPDP can reliably differentiate hepatocellular tumors.
- To assess the diagnostic performance of Mn-DPDP at various doses.
Main Methods:
- Prospective study of 58 patients with suspected focal hepatic disease.
- Intravenous administration of Mn-DPDP (3, 5, 8, or 10 mumol/kg).
- Evaluation of 203 lesions using MR imaging, with histological confirmation in 32 cases.
Main Results:
- Mn-DPDP-enhanced MR imaging demonstrated high diagnostic accuracy.
- Sensitivity was 100%, specificity 92.0%, and overall accuracy 93.6%.
- The agent provided a 100% negative predictive value for distinguishing tumor types.
Conclusions:
- Mn-DPDP-enhanced MR imaging reliably distinguishes between hepatocellular and non-hepatocellular tumors.
- Enhancement patterns observed with Mn-DPDP are key indicators of tumor origin.
- This contrast agent offers a valuable tool for liver lesion characterization.