[Interaction of NAD with the GABA-ergic system of the rat brain]

After administration of corazole content of gamma-aminobutyric acid (GABA) was increased in the rat brain within 2 min and 10 min by 28% and 80%, respectively. Content of the GABA was distinctly decreased in the prespastic phase. During this period specific binding of 3H-muscimol to the GABA receptors was decreased. NAD at concentrations 10(-6) M and 10(-7) M activated the GABA receptors and inhibited binding of 14C-GABA to the synaptosomes of both intact rats and the animals treated with the convulsant agent. NAD appears to cause an effect as an inhibitory neurotransmitter at the postsynaptic level.