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Hepatic arterial chemoembolization for metastatic endocrine tumors
K R Stokes1, K Stuart, M E Clouse
1Department of Radiology, New England Deaconess Hospital, Boston, MA 02215.
Summary
Chemoembolization using ethiodized oil effectively treats liver metastases from endocrine tumors, reducing hormone secretion and tumor size with minimal complications. This method offers a safer alternative to particulate embolization alone.
Area of Science:
- Interventional Radiology
- Oncology
- Hepatology
Background:
- Hepatic metastases from endocrine tumors present a significant treatment challenge.
- Current treatment options may have limitations in efficacy and safety.
Purpose of the Study:
- To evaluate the safety and effectiveness of chemoembolization with ethiodized oil for hepatic metastases from endocrine tumors.
- To compare this technique with embolization using particulate matter alone.
Main Methods:
- Twenty patients with hepatic islet cell or carcinoid tumor metastases were treated.
- Selective hepatic artery injection of doxorubicin and iopamidol emulsified in ethiodized oil was performed, followed by gelatin foam powder embolization.
Main Results:
- Hormone secretion decreased by 90% in 16 patients with hormonally active tumors within 10 days.
- Average tumor size decreased by 84%, with all patients experiencing symptom relief.
- Seventeen patients remained alive and asymptomatic 6-27 months post-embolization.
Conclusions:
- Chemoembolization with ethiodized oil is an effective treatment for hepatic metastases from endocrine tumors.
- This technique demonstrates reduced morbidity compared to particulate embolization alone.