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Adipocyte beta-adrenoceptor sensitivity influences plasma lipid levels
P Arner1, H Wahrenberg, F Lönnqvist
1Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
|July 1, 1993
Summary
Adipocyte beta-receptor sensitivity influences blood lipid levels, particularly triglycerides and VLDL cholesterol. Lower beta-receptor sensitivity is linked to higher triglyceride levels, suggesting a role in hypertriglyceridemia development.
Area of Science:
- Endocrinology
- Lipid Metabolism
- Molecular Biology
Background:
- Catecholamine stimulation of lipolysis via adipocyte beta-adrenoceptors is crucial for lipid mobilization.
- Understanding beta-receptor sensitivity's impact on circulating lipids is important for metabolic health.
Purpose of the Study:
- To investigate the relationship between adipocyte beta-receptor sensitivity and circulating lipid levels in healthy individuals.
- To determine the role of specific beta-receptor subtypes (beta 1 and beta 2) in this association.
Main Methods:
- Assessed beta-receptor sensitivity using isoprenaline, terbutaline (beta 2), and dobutamine (beta 1) bioassays in 46 healthy subjects.
- Measured plasma triglycerides, VLDL-C, VLDL triglycerides, and apolipoprotein B.
- Utilized radioligand binding assays to determine receptor binding capacity.
Main Results:
- Beta-receptor sensitivity was inversely correlated with total plasma triglycerides, VLDL-C, VLDL triglycerides, and apolipoprotein B.
- Beta 2-receptor sensitivity (terbutaline) showed significant inverse correlations with these lipids, while beta 1-receptor sensitivity and binding capacity did not.
- Beta-receptor sensitivity explained 40% of the variance in total plasma triglycerides.
Conclusions:
- Adipocyte beta-receptor sensitivity, particularly via beta 2-receptors, plays a significant role in lipoprotein metabolism, especially VLDL.
- This relationship appears to involve a postreceptor mechanism in lipolysis regulation.
- Low beta-receptor sensitivity may contribute to the development of hypertriglyceridemia.