[The association of human leucocyte antigen (HLA) with posthepatitic cirrhosis]

HLA class I and class II antigens from 61 patients with posthepatitic cirrhosis and 29 HBsAg healthy carrier were examined by using the standard serum including 105 specificities in A, B, C, DQ and DR Loci of HLA provided by the 11th International Histocompatibility Workshop. The results showed the frequencies of HLA-B35 and DR3 were elevated in posthepatitic cirrhosis group as compared with the healthy control group (P < 0.001). The data showed that the frequencies of HLA-B8, C1 were significantly increased, while those of HLA--DR8 more significantly decreased in posthepatitic cirrhotic patients than in health virus carriers. Compared to the healthy controls, however, the frequencies of all 105 HLA specificities examined were identical to healthy carriers.