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Nedocromil sodium

R C Parish1, L J Miller

  • 1College of Pharmacy, University of Georgia, Athens 30602.

The Annals of Pharmacotherapy
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

Nedocromil sodium offers benefits for chronic asthma and allergic rhinitis but doesn't outperform existing treatments. Individual patient responses vary, with no clear predictors for effectiveness.

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Area of Science:

  • Pharmacology and pharmacokinetics of nedocromil sodium.
  • Clinical efficacy in asthma and allergic rhinitis.

Background:

  • Nedocromil sodium is a new agent for managing chronic asthma and allergic rhinitis.
  • Understanding its pharmacokinetic and pharmacologic profile is crucial for clinical application.

Purpose of the Study:

  • To review pharmacokinetic and pharmacologic data of nedocromil sodium.
  • To present clinical trial data for mild-to-moderate and severe chronic asthma and allergic rhinitis.
  • To review adverse effects of nedocromil sodium.

Main Methods:

  • MEDLINE search for English-language literature, excluding reviews.
  • Discussion of pivotal and representative studies on pharmacology, pharmacokinetics, and clinical use.
  • Comparison with sodium cromoglycate and inhaled beclomethasone dipropionate.

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Main Results:

  • Nedocromil sodium shares pharmacology, pharmacokinetics, and benefits with cromolyn but is chemically unrelated.
  • Effective for chronic asthma prophylaxis and allergic rhinitis; attenuates exercise-induced asthma.
  • Not superior to cromolyn and comparable or inferior to inhaled beclomethasone; individual responses vary.

Conclusions:

  • Nedocromil sodium can provide significant improvement for some individuals with asthma or allergic rhinitis.
  • No predictive factors identify which patients will respond best to nedocromil sodium.
  • May be a valuable alternative for adults unresponsive to cromolyn.