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Opiate detoxification protocols. A clinical manual

D A Fishbain1, H L Rosomoff, R Cutler

  • 1Comprehensive Pain and Rehabilitation Center, South Shore Hospital, University of Miami, School of Medicine, Florida.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|March 1, 1993
PubMed
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This study reviews opiate detoxification protocols, including methadone, codeine, buprenorphine, and clonidine-based methods. It aims to reduce withdrawal symptoms and prevent relapse in opiate dependence treatment.

Area of Science:

  • Addiction Medicine
  • Pharmacology

Background:

  • Opiate detoxification aims to manage withdrawal symptoms and prevent relapse.
  • Recent advancements include new medications like clonidine for opiate withdrawal treatment.

Purpose of the Study:

  • To review and outline various opiate detoxification protocols.
  • To summarize adjunct medications and strategies for managing drug-seeking behavior during detoxification.

Main Methods:

  • Review of four main substitution/detoxification protocols: methadone, codeine, opiate of choice, and buprenorphine.
  • Presentation of six protocols utilizing clonidine, including one with opiate antagonist precipitated withdrawal.
  • Outline of two naltrexone protocols and review of adjunct medications.

Main Results:

Related Experiment Videos

  • Various protocols exist for opiate detoxification, utilizing different medications and strategies.
  • Clonidine and naltrexone offer alternative approaches to traditional substitution methods.
  • Adjunct medications and behavioral strategies can support detoxification efforts.

Conclusions:

  • Multiple effective protocols exist for opiate detoxification, catering to different patient needs.
  • The choice of protocol should consider minimizing withdrawal and preventing relapse.
  • Further research and clinical application of these diverse protocols are warranted.