Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Meningeal myofibroblastoma

R A Prayson1, M L Estes, J T McMahon

  • 1Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, Ohio 44195-5138.

The American Journal of Surgical Pathology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hamartia in hippocampal sclerosis-associated mesial temporal lobe epilepsy.

Annals of diagnostic pathology·2017
Same author

Re-review of MRI with post-processing in nonlesional patients in whom epilepsy surgery has failed.

Journal of neurology·2016
Same author

Acute vascular (humoral) rejection in non-OKT3-treated cardiac transplants.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Effects of dual pathology on cognitive outcome following left anterior temporal lobectomy for treatment of epilepsy.

Epilepsy & behavior : E&B·2013
Same author

Necrotizing granulomatous meningoencephalitis due to Balamuthia in an immunocompetent child.

Neurology·2011
Same author

Lymphocytic vasculitis presenting as diffuse subcutaneous edema after hepatitis B virus vaccine.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same journal

Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status: A Large Case Series From Single Institution.

The American journal of surgical pathology·2026
Same journal

NF2/Merlin Immunohistochemistry Helps Distinguish Collecting Duct Carcinoma From Upper Tract Urothelial Carcinoma.

The American journal of surgical pathology·2026
Same journal

Neuroendocrine Carcinoma of the Gallbladder: Clinicopathologic and Immunohistochemical Analysis of 31 Cases.

The American journal of surgical pathology·2026
Same journal

Papillary Renal Neoplasm With Reverse Polarity Is a Distinct Distal Nephron-Derived Tumor With Unique Methylation Profile.

The American journal of surgical pathology·2026
Same journal

Biallelic ARID1A Alterations: A Promising Novel Biomarker for Risk Stratification and Management in Pediatric Malignant Hepatocellular Tumors.

The American journal of surgical pathology·2026
Same journal

Absent Cyclin D1 Expression in Myeloid Sarcomas Distinguishes From Malignant Histiocytic Neoplasms: When Morphologic Ambiguity is Deceptive.

The American journal of surgical pathology·2026
See all related articles

This study details a rare benign mesenchymal tumor, myofibroblastoma, found in the meninges. Accurate diagnosis is crucial to distinguish it from aggressive tumors.

Area of Science:

  • Neuropathology
  • Oncology
  • Histopathology

Background:

  • Myofibroblastoma is a rare, benign mesenchymal tumor.
  • Central Nervous System (CNS) involvement is exceptionally uncommon, with only one prior reported case.
  • Distinguishing benign myofibroblastomas from malignant meningeal tumors is critical for patient management.

Observation:

  • A second case of meningeal myofibroblastoma is presented in a 70-year-old female experiencing visual disturbances.
  • Histological examination revealed alternating spindled and rounded cells with collagen and amianthoid fibers.
  • Immunohistochemistry showed vimentin and focal smooth-muscle actin positivity, with negative staining for other markers (EMA, cytokeratin, S-100, desmin, myosin, GFAP, FVIII-RA).

Findings:

  • Ultrastructural analysis indicated myofibroblasts with characteristics of both smooth muscle cells and fibroblasts.

Related Experiment Videos

  • The tumor's origin is hypothesized to be from meningeal myofibroblasts.
  • The histological and immunohistochemical profile supports a benign myofibroblastoma diagnosis.

    • Implications:

    • This case expands the understanding of myofibroblastomas in the CNS.
    • Accurate differentiation from meningiomas and sarcomas is essential for appropriate treatment and prognosis.
    • Further research into the origin and behavior of meningeal myofibroblastomas is warranted.