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Synthesis and biological activity of bromolignans and cyclolignans
A San Feliciano1, M Medarde, R Pelaez Lamamie de Clairac
1Department of Organic Chemistry, University of Salamanca, Faculty of Pharmacy, Spain.
Archiv Der Pharmazie
|July 1, 1993
Abstract:
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows anti-viral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.