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Results of surgical resection for hepatocellular carcinoma
J Closset1, M Gelin, I el Nakadi
1Service de Chirurgie Digestive, Hôpital Erasme, Université Libre de Bruxelles, Belgique.
Insights
Hepatic resection for hepatocellular carcinoma (HCC) in 35 patients showed an 8.8% postoperative mortality and a 30% 5-year survival rate. Tumor extension and underlying cirrhosis significantly impact outcomes.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastroenterology
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Surgical resection is a primary treatment modality for HCC.
- Understanding outcomes and prognostic factors is crucial for patient management.
Purpose of the Study:
- To evaluate the outcomes of hepatic resection for hepatocellular carcinoma.
- To identify prognostic factors influencing survival after HCC resection.
- To assess the safety and efficacy of surgical treatment for HCC.
Main Methods:
- Retrospective analysis of 35 patients with HCC treated by hepatic resection over 13 years.
- Data collection included patient demographics, tumor characteristics, surgical procedures, complications, and survival rates.
- Statistical analysis focused on identifying prognostic factors.
Main Results:
- The 5-year actuarial survival rate was 30%.
- Tumor extension to one or both lobes and underlying liver cirrhosis were significant prognostic factors.
- Postoperative mortality was 8.8%, with early complications in 57% of patients.
Conclusions:
- Hepatic resection can lead to long-term survival in selected HCC patients.
- Tumor extension and liver cirrhosis are critical determinants of survival.
- Careful patient selection and surgical expertise are essential for optimizing HCC resection outcomes.
Abstract:
During the past 13-years, 35 patients with hepatocellular carcinoma (HCC) were treated by hepatic resection. There were 11 females and 24 males, the age ranged from 17 to 82 years with a mean of 59 years. HCC was associated with liver cirrhosis in 17 patients (48%). Fifteen patients underwent a major hepatectomy, 18 patients a partial hepatectomy (single or bisegmentectomy) and 2 patients had a wedge resection. One patient presenting with a spontaneous tumor rupture died immediately after surgery. Out of the 34 others, 3 died in the postoperative period (8.8%). Early complications occurred in 57% of the patients. The actuarial 5-years survival rate is 30%. The only prognostic factor is tumor extension to a single or both lobes. A significant difference in the survival rate has been observed between patients with or without underlying cirrhosis. Our experience suggest that long-term survival can be expected after surgical resection for HCC.