Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum lipoproteins and hemostatic function in intermittent claudication

J Johansson1, N Egberg, H Johnsson

  • 1Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.

Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing Systemic Risk Assessment for Complex, Interdependent Systems: A Research Agenda.

Risk analysis : an official publication of the Society for Risk Analysis·2026
Same author

Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial.

Critical care (London, England)·2024
Same author

Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre, randomised, controlled NeoRes II trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007-2015.

The journal of nutrition, health & aging·2023
Same author

Burden of in-hospital care in oesophageal cancer: national population-based study.

BJS open·2021
Same author

Impact of surgical resection rate on survival in gastric cancer: nationwide study.

BJS open·2021

Men with intermittent claudication show altered lipoprotein profiles, including lower high-density lipoprotein (HDL) and elevated lipoprotein(a) [Lp(a)]. Hemostatic factors like plasminogen activator inhibitor-1 (PAI-1) and fibrinogen are also increased, indicating coagulation system activation.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Lipidology

Background:

  • Intermittent claudication (IC) is a manifestation of peripheral artery disease, often linked to systemic atherosclerosis.
  • Lipoprotein metabolism and hemostatic function are critical in cardiovascular health and disease progression.

Purpose of the Study:

  • To compare plasma lipoprotein and hemostatic variables between normoglucemic men with IC and matched controls.
  • To investigate correlations between lipoprotein(a) [Lp(a)] and coagulation markers.
  • To identify independent predictors of IC.

Main Methods:

  • Comparison of plasma lipoprotein profiles (including HDL subclasses and Lp(a)) and hemostatic variables (PAI-1, antiplasmin, fibrinogen, beta-thromboglobulin) between IC patients (n=41) and controls (n=75).

Related Experiment Videos

  • Correlation analyses between Lp(a), coagulation factors, and HDL subclasses.
  • Multiple regression analysis to identify independent predictors of IC.

    • Main Results:

    • IC patients exhibited lower levels of large HDL particles (HDL2b, HDL2a, HDL3a) and higher Lp(a) concentrations compared to controls.
    • Elevated levels of plasminogen activator inhibitor-1 (PAI-1), plasma antiplasmin, plasma fibrinogen, and urine beta-thromboglobulin were observed in IC patients.
    • Lp(a) correlated with plasma fibrinogen and urine fibrinopeptide A, while PAI-1 activity correlated with HDL3b and inversely with HDL2b.
    • PAI-1, plasma fibrinogen, and HDL3a were identified as independent predictors of IC (R2 = .36).
    • A subgroup of IC patients on beta-blockers/thiazides showed higher coronary heart disease frequency, elevated triglycerides, lower HDL cholesterol, and a shift towards smaller HDL particles.

    Conclusions:

    • Normoglucemic men with intermittent claudication display dyslipidemia characterized by reduced large HDL particles and increased Lp(a).
    • Abnormalities in hemostatic variables, particularly PAI-1 and fibrinogen, are associated with intermittent claudication.
    • These findings highlight the complex interplay of lipid and hemostatic factors in the pathophysiology of intermittent claudication.