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Related Experiment Videos

Serial quantitative EEG among elderly subjects with delirium

S A Jacobson1, A F Leuchter, D O Walter

  • 1Quantitative EEG Laboratory, UCLA Neuropsychiatric Institute and Hospital.

Biological Psychiatry
|August 1, 1993
PubMed
Summary

Quantitative electroencephalography (QEEG) can track changes in cognitive function in elderly individuals. Specific QEEG measures correlate with cognitive decline in delirium and dementia, offering diagnostic potential.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Clinical Neurophysiology

Background:

  • Delirium and dementia are common in the elderly, impacting cognitive function.
  • Quantitative electroencephalography (QEEG) offers objective measures of brain activity.
  • Serial assessments are crucial for understanding disease progression and treatment efficacy.

Purpose of the Study:

  • To identify specific QEEG variables associated with changes in cognitive state.
  • To explore the clinical utility of QEEG in differentiating and monitoring elderly neurological conditions.
  • To correlate QEEG findings with serial Mini-Mental State Examination (MMSE) scores.

Main Methods:

  • Serial quantitative electroencephalographic (QEEG) studies were conducted on 33 elderly subjects (delirium, dementia, control).

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  • Conventional EEGs and brain maps were independently rated by electroencephalographers.
  • Correlational analyses examined relationships between QEEG variables and MMSE score changes.

    • Main Results:

    • In delirium, relative power map changes and alpha band relative power changes correlated significantly with MMSE changes.
    • In dementia, absolute power map changes and delta band absolute power changes correlated significantly with MMSE changes.
    • Minimal MMSE changes were observed in the control group over time.

    Conclusions:

    • QEEG variables, specifically relative alpha power and power maps, show significant associations with cognitive changes in delirium.
    • Absolute delta power and power maps are associated with cognitive changes in dementia.
    • QEEG provides a quantitative, serial measure for assessing delirium severity and has diagnostic potential.