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Updated: Aug 19, 2026

Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs
Published on: December 27, 2016
Lymphocyte proliferation induced by pertussis toxin utilizes a pathway parallel to transforming growth
Abstract:
Pertussis toxin (PTX) has been shown to potentiate autoimmunity in experimental autoimmune disease. The exact mechanism of this effect has not been determined; however, the modification of G proteins by ADP-ribosylation has been suggested. Here it is demonstrated that this modification may contribute to autoimmunity by the abrogation of transforming growth factor-beta (TGF-beta) growth-inhibitory signals. Anti-TGF-beta demonstrated the same effect on lymphocytes as high concentrations of PTX in vitro.
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