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c-myc expression in renal carcinoma: correlation with clinical parameters
D Lanigan1, P A McLean, D M Murphy
1Department of Urology, Beaumont Hospital, Dublin, Ireland.
British Journal of Urology
|August 1, 1993
Summary
This study investigated the c-myc oncogene in renal carcinomas, finding its expression correlates with tumor stage and grade, but offers no independent prognostic value for patient survival.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- The c-myc oncogene is known to be expressed in renal carcinomas.
- c-myc expression has been linked to the histological grade of these tumors.
Purpose of the Study:
- To investigate the clinical correlations between c-myc oncogene expression and the clinical features of renal carcinoma.
- To determine if c-myc oncoprotein levels provide prognostic information in renal cancer patients.
Main Methods:
- Immunohistochemical staining of c-myc oncoprotein in tissue sections from 97 renal carcinoma patients.
- Scoring of tumors for the extent and intensity of nuclear and cytoplasmic staining.
- Clinical follow-up data from 90 patients were analyzed for correlations with expression levels.
Main Results:
- High levels of c-myc expression significantly correlated with increased T category (tumor size/invasion) and nuclear grade.
- Venous invasion was also significantly associated with higher c-myc expression.
- No significant correlation was found with nodal involvement, metastasis presence, tumor architecture, or cell type.
Conclusions:
- While c-myc expression correlates with certain tumor characteristics like stage and grade, it does not offer independent prognostic information.
- Semiquantitative assessment of c-myc oncoprotein levels is not clinically useful for predicting patient outcomes in renal carcinoma.