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Urinary selenium concentrations

M Sanz Alaejos1, C Díaz Romero

  • 1Department of Analytical Chemistry, Food Science, and Toxicology, University of La Laguna, Tenerife, Spain.

Clinical Chemistry
|October 1, 1993
PubMed
Summary
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Urinary selenium (Se) levels reflect dietary intake and status. Normal excretion (20-200 µg/day) avoids toxicity, but varies in specific populations and health conditions.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Urinary selenium concentration is a key biomarker for assessing selenium status.
  • Dietary selenium intake strongly correlates with urinary selenium excretion globally.
  • Kidneys play a crucial role in regulating selenium homeostasis.

Purpose of the Study:

  • To review urinary selenium concentrations in various populations and pathological conditions.
  • To establish reference ranges for urinary selenium excretion.
  • To understand factors influencing selenium status and excretion.

Main Methods:

  • Literature review of studies on urinary selenium concentrations.
  • Analysis of data from healthy individuals and patient groups.

Related Experiment Videos

  • Examination of selenium bioavailability and balance studies.

    • Main Results:

    • A wide range of urinary selenium excretion (20-200 µg/day) is generally safe.
    • Urinary Se excretion is lower in children, the elderly, and pregnant women.
    • Elevated urinary Se in heavy metal-exposed workers and decreased levels in cancer patients were observed.

    Conclusions:

    • Urinary selenium is a reliable indicator of selenium status, influenced by diet and physiological state.
    • Kidney function is vital for maintaining selenium balance.
    • Trimethylselenonium ion plays a role in detoxifying excess selenium intake.