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Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
J D Brioni1, A B O'Neill, D J Kim
1Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500.
European Journal of Pharmacology
|July 6, 1993
Summary
Nicotine and lobeline act as anxiolytics in mice, reducing anxiety behaviors. This effect is mediated by central nicotinic receptors, not peripheral ones, offering potential therapeutic insights.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Anxiety disorders are prevalent, necessitating novel therapeutic targets.
- Nicotinic acetylcholine receptors (nAChRs) are implicated in various brain functions, including mood regulation.
Purpose of the Study:
- To investigate the anxiolytic-like effects of nicotinic receptor agonists.
- To determine the role of central versus peripheral nicotinic receptors in mediating these effects.
Main Methods:
- CD1 mice were administered nicotinic receptor agonists and antagonists.
- Behavior was assessed using the elevated plus-maze test.
- Specific antagonists (mecamylamine, chlorisondamine, hexamethonium) were used to differentiate receptor locations.
Main Results:
- Nicotine and lobeline significantly increased time spent in open arms, indicating anxiolytic activity.
- Central nicotinic receptor antagonists blocked nicotine's anxiolytic effect, while peripheral antagonists did not.
- Cotinine, nicotine's metabolite, showed no anxiolytic effect.
Conclusions:
- Nicotine and lobeline exhibit anxiolytic-like properties in mice.
- Central nicotinic receptors mediate these anxiolytic effects.
- Nicotinic receptor stimulation may offer an alternative to benzodiazepines for anxiety treatment.