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Related Experiment Videos

Calcitonin gene expression in normal human liver

S Bracq1, M Machairas, B Clement

  • 1INSERM U349, Centre Viggo Petersen, Paris, France.

FEBS Letters
|September 27, 1993
PubMed
Summary

The calcitonin gene is expressed in the liver, indicating the human liver synthesizes this hormone. This suggests a potential autocrine or paracrine system involving calcitonin within the liver.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Hepatology

Background:

  • Immunoreactive calcitonin (CT) has been detected in the liver.
  • The liver expresses calcitonin receptors, suggesting a potential role for CT in this organ.

Purpose of the Study:

  • To investigate the expression of the calcitonin gene in human liver tissue and hepatocytes.
  • To determine if the liver synthesizes calcitonin.

Main Methods:

  • Polymerase chain reaction (PCR) amplification of calcitonin messenger RNA (mRNA) in human liver and primary hepatocyte cultures.
  • Radioimmunoassay (RIA) to detect calcitonin in hepatic tissues and cells.

Main Results:

  • Calcitonin gene expression was confirmed in human liver and hepatocytes via PCR.

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  • Calcitonin was detected in hepatic tissues and cells using RIA.
  • The presence of both CT synthesis and receptors suggests an autocrine/paracrine system.

    • Conclusions:

    • The human liver expresses the calcitonin gene and synthesizes calcitonin.
    • A calcitonin autocrine or paracrine system may operate within the liver.