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Updated: Aug 18, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
Published on: July 14, 2010
beta-Amyloid neurotoxicity
1Neurobiology of Alzheimer Unit, Mario Negri, Institute of Pharmacological Research, Milan, Italy.
Abstract:
beta-amyloid (beta A, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death. beta A, a portion of a larger transmembrane glycoprotein, has been reported to be toxic in several tissue culture models. The neurotoxic activity of beta A synthetic peptides is associated with their fibrillogenic capacity. However, in vivo studies on beta A neurotoxic activity have not proved conclusive and further investigations are necessary to establish the pathogenetic role of beta A in AD.
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