Comparative mapping of the Grpr locus on the X chromosomes of man and mouse

The gastrin-releasing peptide receptor has been previously cloned from both humans and mice. We have mapped the mouse gastrin-releasing peptide receptor (Grpr) locus using a polymorphic CAn repeat located in the 5' untranslated region of the gene and a Mus spretus/Mus musculus interspecific backcross. The Grpr locus mapped between the Pdha-1 and Amg loci on the mouse X chromosome. Studies in man indicate that GRPR maps to the Xp21.2-p22.3 region of the human X chromosome and not to the Xp11-q11 interval as previously reported. The assignment of the GRPR locus to the distal Xp region is supported by the comparative map position in the mouse.