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9a,11-cyclic carbamates of 15-membered azalides
G Kobrehel1, G Lazarevski, Z Kelnerić
1PLIVA, Research Institute, Prilaz baruna Filipovića, Croatia.
The Journal of Antibiotics
|August 1, 1993
Abstract:
The novel 9a,11-cyclic carbamates (13-15) of 9-deoxo-9a-aza-9a-homoerythromycin A (4) have been prepared and characterized by 1H-1H and 1H-13C 2D NMR spectroscopy. When compared to azithromycin (1) or its 6-O-methyl derivative (2), the new bicyclic 15-membered azalides exhibited substantially decreased antibacterial activities in vitro.