Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement polymorphism in herpes gestationis: association with C4 null allele

J K Shornick1, C M Artlett, R E Jenkins

  • 1St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK.

Journal of the American Academy of Dermatology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

Nature communications·2023
Same author

C-Reactive Protein and Covid-19 Severity: A Systematic Review.

West African journal of medicine·2021
Same author

HLA-and Gm-linked genes and antigen non-specific immunoregulation.

Immunology today·2014
Same author

Significant IgG subclass heterogeneity in HLA-specific antibodies: Implications for pathogenicity, prognosis, and the rejection response.

Human immunology·2013
Same author

CC chemokine receptor 5 gene polymorphisms in beryllium disease.

The European respiratory journal·2010
Same author

CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis.

The European respiratory journal·2009

Herpes gestationis (HG) is linked to a specific genetic factor. Ninety percent of patients with this pregnancy-related skin disease possess a C4 null allele (C4*QO).

Area of Science:

  • Immunogenetics
  • Dermatology
  • Pregnancy Complications

Background:

  • Herpes gestationis (HG) is a rare autoimmune blistering disease of pregnancy.
  • It involves autoantibodies targeting hemidesmosome components.
  • Previous studies linked HG to HLA-DR3 and HLA-DR4, but not complement system's class III antigens.

Purpose of the Study:

  • To investigate the association between complement system polymorphism and herpes gestationis.
  • To determine allele frequencies of specific complement components in HG patients.

Main Methods:

  • Electrophoresis and immunofixation techniques were employed.
  • Allele frequencies of C4A, C4B, C3, and factor B were analyzed.
  • Study included 42 patients with a history of HG.

Related Experiment Videos

Main Results:

  • A high prevalence of the C4 null allele (C4*QO) was observed, present in 90% of patients.
  • No significant association was found with C3 or factor B alleles.
  • The C4*QO allele appears strongly linked to HG.

Conclusions:

  • Herpes gestationis is associated with the C4*QO allele.
  • Further research is needed to clarify if C4*QO is the primary genetic factor or linked to HLA-DR3/DR4.
  • This finding may offer insights into HG pathogenesis.