Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does ozone alleviate AIDS diarrhea?

M T Carpendale1, J Freeberg, J M Griffiss

  • 1Rehabilitation Medicine Service, San Francisco Veterans Administration Medical Center (SFVAMC) 94121.

Journal of Clinical Gastroenterology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and pharmacokinetics of XOMA 3AB, a novel mixture of three monoclonal antibodies against botulinum toxin A.

Antimicrobial agents and chemotherapy·2014
Same author

Stability of colistimethate sodium in aqueous solution.

Antimicrobial agents and chemotherapy·2012
Same author

Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers.

Sexually transmitted diseases·2001
Same author

CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells.

Cellular microbiology·2001
Same author

Pigment gallstone pathogenesis: slime production by biliary bacteria is more important than beta-glucuronidase production.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2000
Same author

Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis.

Infection and immunity·2000
Same journal

GLP-1 Receptor Agonists and Hepatic Encephalopathy in Cirrhosis: A Protective Signal Requiring Cancer and Nutritional Phenotyping.

Journal of clinical gastroenterology·2026
Same journal

Endoscopic Incisional Therapy for Benign Esophageal Strictures: A Systematic Review and Meta-Analysis.

Journal of clinical gastroenterology·2026
Same journal

International Consensus Statements on the Use of Topical Endoscopic Hemostatic Powders in the Treatment of Acute Gastrointestinal Bleeding.

Journal of clinical gastroenterology·2026
Same journal

Do Risk Factors for Reflux Symptoms After Peroral Endoscopic Myotomy Necessarily Increase the Occurrence of Postoperative Gastroesophageal Reflux?

Journal of clinical gastroenterology·2026
Same journal

Subgroup Stratification by Regimen, Geography, and Population Is Necessary to Validate Nitazoxanide-based Helicobacter pylori Eradication Therapy.

Journal of clinical gastroenterology·2026
Same journal

The Impact of Glucagon-Like Peptide 1 Receptor Agonists Versus Diabetes Mellitus on Endoscopic Procedures: A Case-Control Study From a Large Tertiary Care Health System.

Journal of clinical gastroenterology·2026
See all related articles

Medical ozone therapy via rectal insufflation shows promise for treating intractable diarrhea in patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC). This safe and simple treatment led to significant symptom resolution in most participants.

Area of Science:

  • Immunology
  • Gastroenterology
  • Ozone Therapy

Background:

  • Intractable diarrhea is a common and debilitating complication in patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC).
  • Conventional treatments may be ineffective for some patients, necessitating exploration of alternative therapeutic options.

Purpose of the Study:

  • To evaluate the safety and efficacy of medical ozone therapy administered by colonic insufflation for intractable diarrhea in patients with ARC/AIDS.

Main Methods:

  • Five patients with ARC/AIDS and intractable diarrhea received daily colonic insufflations of an oxygen/ozone mixture for 21-28 days.
  • Ozone doses ranged from 2.7 to 30 mg daily.
  • Clinical outcomes, lymphocyte counts (CD4, CD8), blood gases, and routine blood work were monitored.

Related Experiment Videos

Main Results:

  • Three of four patients with diarrhea of unknown etiology experienced complete resolution; one had marked improvement.
  • The patient with Cryptosporidium-induced diarrhea showed no change.
  • No significant adverse systemic effects were observed, though mild local discomfort occurred initially.
  • No consistent changes in CD4/CD8 counts or routine blood parameters were detected.

Conclusions:

  • Medical ozone administered by rectal insufflation appears to be a simple, safe, and potentially effective treatment for intractable diarrhea in certain ARC/AIDS patients.
  • Further investigation is warranted to determine its routine clinical utility for chronic ARC/AIDS-related diarrhea.